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Firstly 2-mcf online is very similar with 2-methyl-maf .2-mcf for sale online

And the physiological and toxicological properties of this compound are not know. This product is intend for forensic and research applications.

The present investigation aim to examine the therapeutic potential of the new coumarin derivative bis(4-hydroxy-2H-chromen-2-one) coumarin (4HC) against breast cancer.

Materials and methods: 

Importantly for this purpose, the effects of 4HC treatment on the proliferation of MCF-7 breast cancer cells and on MCF-10a non-cancerous cells are evaluate using a fluorescent assay. Cell cycle distribution and apoptosis are measure by image cytometry. The expression level of aromatase (CYP19A1) and apoptosis-relate genes were determine by real-time PCR.


  Subsequently MCF-7 mammary cancer cell proliferation was significantly decreased within 24 h after treatment with 4HC at 50 μM, while no effect was observed on the viability of MCF-10a non-cancerous mammary cells. 4HC also increased the percentage of the cells in the G2/M phase, inducing apoptosis. Real-time PCR revealed that 4HC induced MCF-7 mortality through an up-regulation of Bax and a down-regulation of Bcl-2, resulting in an increase in caspase-3 gene expression. The increased expression of apoptosis-related genes was accompanied by a decrease in CYP19A1 gene expression. Buy 2-mcf online


Lastly 4HC selectively inhibits proliferation of MCF-7cells in vitro. Moreover  4HC has inhibitory effects on aromatase gene expression and promoting effects on apoptosis, in MCF-7 cells.


 Bis(4-hydroxy-2H-chromen-2-one); Coumarin derivative; MCF-7 breast cancer cells; apoptosis; aromatase inhibition; breast cancer; cell cycle; cell proliferation.

Furthermore in connection with our continue research to generate new aza-fused heteroaromatic chemical scaffolds. Also we developed a highly atom-economical three-component route to novel 3,4-dihydropyrrolo[1,2-a]pyrazine ring skeleton multi-functionalize

on the pyrazine unit. This [4+1+1] annulation approach led us to gain access to a new N-fused bicyclic chemical space having two distinctive functional groups (heteroaryl and aroyl) in a trans manner. And Investigation of anticancer activity of the synthesized compounds. Moreso their derivatives reveal that (3R*,4S*)-3-(4-bromophenyl)-4-(4-fluorobenzoyl)-2-(2-oxo-2-phenylethyl)-3,4-dihydropyrrolo[1,2-a]pyrazin-2-ium bromide (3h) also has potent anticancer activity. 3h significantly inhibited cell viability in prostate cancer cells (PC-3) and breast cancer cells (MCF-7) with IC50 value of 1.18 ± 0.05 μM and 1.95 ± 0.04 μM, respectively. In addition 3h strongly reduced cell migration in a dose dependent manner certainly induced apoptosis via caspase-3 activation and cleavage of PARP in PC-3 and MCF-7 cells.

In the same vein our results in this study imply that 3h can be a potential anticancer agent against prostate cancer and breast cancer.


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